Evidence of the effectiveness of tight control in daily clinical practice is shown in various studies. These studies are joined in the following meta-analysis: Meta-analysis of tight control strategies in rheumatoid arthritis: protocolized treatment has additional value with respect to the clinical outcome:

Schipper, L.G. et al., Rheumatology 2010;49;2154-64. 


DAS28 is an objective measurement and when medication is adapted when the score is more than 3.2 the disease activity of patients will decrease, the chance of damage decreases and the functionality of patients increases. So, it is important to use the instrument in daily clinical practice to improve the care of RA patients and improve the outcomes of patients.





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